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|InsulinQC™ - Monitoring gel, fibrillar and pre-fibrillar formation
InsulinQC™ is a method for determination of pre-fibrillar and fibrillar insulin species in a given sample. The evaluation is done
by means of fluorescence spectroscopy and it is possible to detect ultra-low levels of pre-fibrillar species and thereby determining the
quantity of pre-fibrillar and fibrillar protein species. InsulinQC is for "Research and Development Use" only.
The Insulin-QC kit is superior to conventional fibrils detection probes such as Thioflavine T (ThT). This novel and superior method is
based on BioChromix's patented optical Apolyon™ probes.
InsulinQC™ - Assays for pre-fibrillar Insulin species
InsulinQC™ is a unique kit for specific determination the level of pre-fibrillar to fibrillar insulin species making it suitable in
insulin biopharmaceutical production. Gel and fibril formation can occur biopharma production InsulinQC™ provides simple means to
assay unwanted species. High specificity and sensitivity offers the possibility to detect ultra-low levels of pre-fibrillar species.
Read more (PDF).
For inquiries and orders, please go to On-line ordering or contact
Advantages of BioChromix InsulinQC™ kit: The control of insulin is fast, easy, robust and does not, in most cases, require
heat incubation of the insulin sample. The BCX500 is a unique probe that detects very early pre-fibrillar states indicative of low
insulin batch quality.
Patent pending: InsulinQC™ is protected by US 11/579,741 including corresponding applications and additional patent pending
Example: Insulin fibrillation kinetecs, 0 min only native insulin present and increasing number and size of insulin aggregates with time.
Left) Insulin fibrillation kinetics monitored with BCX500. A strong signal increase in the fluorescence ratio RIns_QC is obvious already after
a little bit more than 20 min. Right) Insulin fibrillation kinetics monitored with ThT. A signal increase can be seen after 100-200 min, but
a strong signal increase is only evident after more than 200 min.
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